1 Celulas B16 2 Linfocitos B 1 3 Erk 4 Metastases
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1. Modificação fenotípica do melanoma murino induzida pela interação com células B-1 - Mecanismos de transdução de sinal. / B-1 lymphocytes increase metastatic behavior of melanoma cells through the extracellular signal-regulated kinase pathway.
Increasing evidence indicates that tumors require a constant influx of myelomonocytic cells to support their malignant behavior. This is caused by tumor- derived factors, which recruit and induce functional differentiation of myelomonocytic cells, most of which are macrophages. Although myeloid lineages are the classical precursors of macrophages, B lymphoid
Publicado em: 2007