5 Ht2c Receptors
Mostrando 1-12 de 87 artigos, teses e dissertações.
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1. Association between serotonin 2C receptor gene (HTR2C) polymorphisms and psychopathological symptoms in children and adolescents
Serotonin 2C receptors (5HT2C) are involved in serotonin-driven dynamic equilibrium adjustments responsible for homeostatic stability in brain structures that modulate behavior and emotions. Single nucleotide polymorphisms (SNPs) from the serotonin 2C receptor gene (HTR2C) have been associated with several neurological and mental disorders, including abnorma
Braz J Med Biol Res. Publicado em: 14/06/2018
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2. ADME studies and preliminary safety pharmacology of LDT5, a lead compound for the treatment of benign prostatic hyperplasia
This study aimed to estimate the absorption, distribution, metabolism and excretion (ADME) properties and safety of LDT5, a lead compound for oral treatment of benign prostatic hyperplasia that has previously been characterized as a multi-target antagonist of α1A-, α1D-adrenoceptors and 5-HT1A receptors. The preclinical characterization of this compound co
Braz J Med Biol Res. Publicado em: 24/11/2016
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3. Association of terpinolene and diclofenac presents antinociceptive and anti-inflammatory synergistic effects in a model of chronic inflammation
Pharmacological treatment of inflammatory pain is usually done by administration of non-steroidal anti-inflammatory drugs (NSAIDs). These drugs present high efficacy, although side effects are common, especially gastrointestinal lesions. One of the pharmacological strategies to minimize such effects is the combination of drugs and natural products with syner
Braz J Med Biol Res. Publicado em: 20/06/2016
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4. O bloqueio dos receptores 5-HT2 da substância cinzenta periaquedutal suprime o efeito ansiolítico resultante do antagonismo dos receptores 5-HT1A do núcleo mediano da rafe em camundongos / Blockade of 5-HT2 receptors in the periaqueductal grey matter (PAG) abolishes the anxiolytic-like effect of 5-HT1A receptor antagonism in the median raphé nucleus in mice. 2011.
Várias evidências apontam o envolvimento de neurônios serotoninérgicos do núcleo mediano da rafe (NMnR) na ansiedade. Sabe-se que o bloqueio dos autorreceptores somatodendríticos dos núcleos da rafe aumenta a taxa de disparo dos neurônios serotoninérgicos, promovendo a liberação de serotonina em sítios pós-sinápticos como amígdala, hipocampo e
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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5. PERFIL FARMACOLÓGICO DO TIPO ANTIDEPRESSIVO DO COMPOSTO 3-(4-FLUOROFENILSELENIL)-2,5 DIFENILSELENOFENO: ENVOLVIMENTO DO SISTEMA SEROTONINÉRGICO / ANTIDEPRESSANT-LIKE PHARMACOLOGICAL PROFILE OF 3-(4- FLUOROPHENYLSELENYL)-2,5-DIPHENYLSELENOPHENE: INVOLVEMENT OF SEROTONERGIC SYSTEM
Depression is a serious, recurrent and incapacitating psychiatric condition with a heavy social burden. The pharmacological approach to this disorder employs therapy with antidepressant drugs, which have side effects and numerous limitations. In view of the promising pharmacological properties of containing-selenium molecules, this study evaluated the effect
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 23/02/2011
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6. Central 5-HT2A receptors modulate the vagal bradycardia in response to activation of the von Bezold-Jarisch reflex in anesthetized rats
Activation of 5-hydroxytryptamine (5-HT) 5-HT1A, 5-HT2C, 5-HT3, and 5-HT7 receptors modulates the excitability of cardiac vagal motoneurones, but the precise role of 5-HT2A/2B receptors in these phenomena is unclear. We report here the effects of intracisternal (ic) administration of selective 5-HT2A/2B antagonists on the vagal bradycardia elicited by activa
Braz J Med Biol Res. Publicado em: 2011-03
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7. Antidepressant- and anxiogenic-like effects of acute 5-HT2C receptor activation in rats exposed to the forced swim test and elevated plus maze
This study investigated the behavioral effects in the forced swim test (FST) and the elevated plus-maze (EPM) of acute administration of WAY 161503 ([4aR]-8,9-dichloro-2,3,4,4a-tetrahydro-1H-pyrazino[1,2-a]quinoxalin-5[6 H]-one), a selective 5-HT2C receptor agonist with putative antidepressant-like properties. Fifteen minutes after intraperitoneal (i.p.) inj
Psychology & Neuroscience. Publicado em: 2010-12
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8. Envolvimento dos receptores 5-HT2c do hipocampo ventral na modulação de estados de ansiedade em ratos
The present study investigated the effects of pharmacological blockade of 5-HT2C receptors of the ventral hippocampus (VH) on anxiety levels of rats induced by 5-HT2C agonists. Ten minutes after intraperitoneal (i.p.) injections of either saline (0.9%) or the 5-HT2C agonist WAY-161503 (3mg/kg), rats were bilaterally microinjected in the VH with saline or wit
Publicado em: 2010
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9. Avaliação dos receptores 5-HT2C na expressão da sensibilização comportamental ao efeito estimulante do etanol. / Evaluation of 5-HT2C receptors on the expression of behavioral sensitization to the stimulant effect of ethanol
Não consta abstract.
Publicado em: 2010
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10. Administração prolongada do ácido 13-cis-retinóico (isotretinoína) em camundongos machos adolescentes: comportamentos emocionais e quantificação de transcritos de componentes do sistema serotoninérgico central. / Chronic administration of 13-cis-retinoic acid (isotretinoin) in young male mice: emotion-related behaviors and quantification of central serotonergic system transcripts.
O ácido 13-cis-retinóico (13-cis-RA, isotretinoína) é um retinóide sintético de uso oral prolongado, prescrito em altas doses, para o tratamento da acne. Age primariamente diminuindo a atividade da glândula sebácea e reduzindo a inflamação. Desde a aprovação do uso do 13-cis-RA, tem-se relatos na literatura de sintomas psiquiátricos incluindo de
Publicado em: 2010
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11. InvestigaÃÃo dos efeitos centrais e gastroprotetores do isopulegol em camundongos / Evaluation of the central nervous system and gastroprotective effects of isopulegol in mice.
Isopulegol is a monoterpene alcohol present in the essential oils of various plants, and has been used in the manufacture of fragrances with blossom compositions. In order to investigate its effects on animal models of CNS actions, isopulegol was administered to male Swiss mice at single doses of 25 and 50 mg/kg 30 (i.p.) or 60 min (p.o.) before the experime
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/08/2009
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12. Avaliação do papel dos receptores 5-HT3 da substância cinzenta periaquedutal de camundongos submetidos ao labirinto em cruz elevado
A exposição de animais a situações aversivas, tais como o labirinto em cruz elevado (LCE), ativa vias serotoninérgicas com projeções para estruturas envolvidas no sistema de defesa tais como, amídala, septo, hipotálamo, hipocampo e substância cinzenta periaquedutal (SCP), produzindo alterações comportamentais que podem ser caracterizadas como ans
Publicado em: 2009