Acetophenones
Mostrando 1-12 de 15 artigos, teses e dissertações.
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1. APPLICATION OF SULFONIC ACID FUNCTIONALIZED NANOPOROUS SILICA (SBA-Pr-SO3H) FOR THE PREPARATION OF 4,6-DIARYLPYRIMIDIN-2(1H)-ONES
In this work, we report the Biginelli-type reaction between various aldehydes, acetophenones and urea systems in the presence of sulfonic acid functionalized silica (SBA-Pr-SO3H) under solvent-free conditions, which led to 4,6-diarylpyrimidin-2(1H)-ones derivatives. SBA-Pr-SO3H with a pore size of 6 nm was found to be an efficient heterogeneous solid acid ca
Quím. Nova. Publicado em: 2015-05
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2. Síntese de organo-seleno aminas e sua resolução cinética via reação de acetilação enantiosseletiva mediada por lipases / Synthesis of organoselenium amines and their kinetic resolution by enantioselective acetylation mediated by lipases
In this work, we have developed a chemoenzymatic method to enantiomerically synthesize enriched organoselenium amines (1-(2, 3 or 4 -(ethylselanyl)phenyl)ethanamine) and amides (N-(1-(2, 3 or 4-(ethylselanyl)phenyl)ethyl)acetamide). Initially, the organoselenium amines, in the racemic form, were synthesized from ortho-, meta- and para- aminoacetophenones. Th
Publicado em: 2008
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3. Diterpenos casbanos e acetofenonas de Croton nepetaefolius (Euphorbiaceae)
Croton nepetaefolius is an aromatic plant native to the northeast of Brazil where it is extensively used in folk medicine as a sedative, orexigen and antispasmodic agent. The present work deals with the chromatographic analysis of the ethanolic extract of Croton nepetaefolius stalk. It allowed the isolation and characterization of two diterpenoids named 1,4-
Química Nova. Publicado em: 2008
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4. Energética e mecanismos de processos iônicos em fase gasosa / Energetics and mechanisms of gas-phase ionic processes
The study of ionic reactivity in the gas-phase has been widely explored with mass spectrometry techniques. This thesis reports experimental and theoretical results in three different areas of gas-phase ion chemistry. The ionic processes were experimentally studied by Fourier transform mass spectrometry (FTMS or FT-ICR), a high resolution method that allows f
Publicado em: 2007
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5. Synthesis and reactivity of alpha-phenylseleno-beta-substituted styrenes: preparation of (Z)-allyl alcohols, (E)-alpha-phenyl-alpha,beta-unsaturated aldehydes and alpha-aryl acetophenones
Foi desenvolvido um método simples e eficiente para a síntese de beta-estirenos alfa-fenilseleno-substituídos, através da reação do alfa-(fenilselenobenzil)fosfonato de dietila e NaH na presença de aldeídos. A reação destes produtos com n-BuLi e posterior captura do ânion com aldeídos ou DMF levou à formação, exclusivamente, de álcoois de con
Journal of the Brazilian Chemical Society. Publicado em: 2006-10
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6. Aromatic compounds containing Selenium and Tellurium: application of biocatalysis for preparation of enatiomerically enriched aromatic selenides and tellurides / Derivados aromáticos de selênio e telúrio: aplicação da biocatálise na preparação de selenetos e teluretos aromáticos enantiomericamente enriquecidos
A primeira parte desta tese consiste na preparação de compostos aromáticos contendo átomos de selênio e de telúrio. Quatro metodologias foram utilizadas para essa finalidade, a saber: orto-metalação de compostos contendo oxigênio, troca metal-halogênio em haletos aromáticos substituídos, reação de substituição eletrofílica aromática entre t
Publicado em: 2005
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7. Novos aspectos e aplicações da química de teluranas e de teluretos orgânicos / New aspects and applications of the chemistry of organotelluranes and organic tellurides
The first part of this thesis deals with the study of the reactivity of electrophilic tellurium compounds, mainly tellurium tetrachloride and aromatic tellurium trichlorides. New aspects of the reactivity of TeCl4 towards alkynes and some acetophenones were disclosed. A mechanistic rationale for each of the processes studied was possible by the determination
Publicado em: 2005
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8. Conformational analysis of ortho and meta-acetophenones α phosphonates and their derivatives substituted: α methylthio; α methylsulphinyl: and α methylsulphonyl and reactivity study of substituted ortho and meta α haloacetophenones with triethylphosphite / Análise conformacional de orto e meta-acetofenonas α -fosfonatos e seus derivados: α-metiltio; α:metilsulfinil; e α-metilsulfonil- substituídas e estudo da reatividade de α-haloacetofenonas orto e meta-substituídas com trietilfosfito
This thesis reports the study of the reactivity of the competitive Michaelis- Arbuzov and Perkow reactions of some orto- and meta- substituted α-haloacetophenones (I) [o- and m-Y-Φ-C(O)CH2-Hal] (Hal = CI, Br e I; Y = OMe, Me, H, F, CI, Br and NO2) with triethyl phosphite, by gas chromatography, and the conformational analysis of some orto- and meta-s
Publicado em: 2003
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9. Bacterial Degradation of Ring-Chlorinated Acetophenones
Two strains, Alcaligenes sp. strain ACA and Pseudomonas fluorescens ACB, isolated from acetophenone and 4′-hydroxyacetophenone enrichments, respectively, cometabolize a range of chlorinated acetophenones (CAs). A biological Baeyer-Villiger reaction converts the CA to chlorophenyl acetate. This is evident only in the presence of an esterase inhibitor, since
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10. Microbial degradation of chlorinated acetophenones.
A defined mixed culture, consisting of an Arthrobacter sp. and a Micrococcus sp. and able to grow with 4-chloroacetophenone as a sole source of carbon and energy, was isolated. 4-Chlorophenyl acetate, 4-chlorophenol, and 4-chlorocatechol were identified as metabolites through comparison of retention times and UV spectra with those of standard substances. The
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11. Structure-dependent reactivity of oxyfunctionalized acetophenones in the photooxidation of DNA: base oxidation and strand breaks through photolytic radical formation (spin trapping, EPR spectroscopy, transient kinetics) versus photosensitization (electron transfer, hydrogen-atom abstraction)
The photooxidative damage of DNA, specifically guanine oxidation and strand-break formation, by sidechain-oxyfunctionalized acetophenones (hydroxy, methoxy, tert-butoxy and acetoxy derivatives), has been examined. The involvement of triplet-excited ketones and their reactivity towards DNA has been determined by time-resolved laser-flash spectroscopy. The gen
Oxford University Press.
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12. Inhibition of the Cathepsin D-Type Proteinase of Macrophages by Pepstatin, a Specific Pepsin Inhibitor, and Other Substances
The macrophage is the main cell participating in chronic inflammation. It contains an acid-acting, cathepsin D-type proteinase with the specificity of pepsin, which may release mediators of the inflammatory process. To find new pharmaceutical inhibitors of this proteinase, we tested a variety of chemical compounds in vitro. For this survey, the possible inhi