Acido Pirazinoico
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1. Synthesis and antimycobacterial activity of pyrazinoic acid esters and quinolones / Síntese e atividade antimicobacteriana de ésteres do ácido pirazinóico e quinolonas
Tuberculosis affects over than one billion people around the world. Since the discovery of rifampin, in 1965, no one another important drug was introduced in therapeutics. Pyrazinamide, one of the drugs available in therapy of tuberculosis, is nowadays considered a bioprecursor of pyrazinoic acid, because resistant bacterias do not express an enzyme, pyrazin
Publicado em: 2006