Activin Follistatin
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Effect of physical training on liver expression of activin A and follistatin in a nonalcoholic fatty liver disease model in rats
Nonalcoholic fatty liver disease (NAFLD) is characterized by fat accumulation in the liver and is associated with obesity and insulin resistance. Activin A is a member of the transforming growth factor beta (TGF)-β superfamily and inhibits hepatocyte growth. Follistatin antagonizes the biological actions of activin. Exercise is an important therapeutic stra
Braz J Med Biol Res. Publicado em: 25/07/2014
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2. Efeitos do exercício físico sobre a expressão hepática de activina A e folistatina em modelo de doença hepática gordurosa não acoólica em ratos
A doença hepática gordurosa não alcoólica (DHGNA) é caracterizada pelo acúmulo de gordura no fígado e está associada à obesidade e à resistência insulínica. A activina A, membro da superfamília do fator de crescimento e transformação β (TGF-β), inibe o crescimento de hepatócitos e induz a apoptose. A folistatina é uma glicoproteín
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/04/2012
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3. Efeitos da ativina A, inibina A e folistatina Sobre células endometriais em um modelo de adesão e invasão peritoneal in vitro.
Objective: The aim of this study was to investigate whether activin A has an effect in the attachment and invasion of endometrial cells in a modeled peritoneum in vitro. Methods: Cultured endometrial stromal and epithelial cells were treated with activin A (concentration range 6.25 to 50 ng/ml) and with activin A 25 ng/ml alone or associated to inhibin A or
Publicado em: 2007
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4. Effects of truncated activin and FGF receptors and of follistatin on the inducing activities of BVg1 and activin: does activin play a role in mesoderm induction?
Activin and Vg1, two members of the TGF-beta family, are believed to play roles in mesoderm induction and axis formation in the amphibian embryo. Both molecules are provided maternally, either as protein (activin) or as RNA and protein (Vg1), and experiments with a truncated form of a type IIB activin receptor have led to the conclusion that activin is requi
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5. Upregulation of activin signaling in experimental colitis
Several lines of studies have suggested that activins are critical mediators of inflammation and tissue repair. As activins and their receptors are expressed in the gastrointestinal tract, we tested the hypothesis that activin signaling is involved in the development of colitis by using two murine models of colitis induced by dextran sodium sulfate (DSS) or
American Physiological Society.
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6. Evidence for the participation of endogenous activin A/erythroid differentiation factor in the regulation of erythropoiesis.
Activin A/erythroid differentiation factor (EDF) is a human protein that induces differentiation of a murine erythroleukemia cell (the Friend cell). In this study, we demonstrate that endogenous activin A/EDF activity is present in murine bone marrow and spleen. In addition, this activity is secreted by bone marrow and spleen cells in primary culture. Admini
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7. Impaired wound healing in transgenic mice overexpressing the activin antagonist follistatin in the epidermis
Recently, we demonstrated a strong upregulation of activin expression after skin injury. Furthermore, overexpression of this transforming growth factor β family member in the skin of transgenic mice caused dermal fibrosis, epidermal hyperthickening and enhanced wound repair. However, the role of endogenous activin in wound healing has not been determined. T
Oxford University Press.
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8. Activin A: an autocrine inhibitor of initiation of DNA synthesis in rat hepatocytes.
The present study was conducted to examine the effect of activin A on growth of rat hepatocytes. EGF induced a 10-fold increase in DNA synthesis as assessed by [3H]thymidine incorporation in cultured hepatocytes. When activin A was added together with EGF, DNA synthesis induced by EGF was markedly inhibited. Inhibition was detected at a concentration of 10(-
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9. Direct binding of follistatin to a complex of bone-morphogenetic protein and its receptor inhibits ventral and epidermal cell fates in early Xenopus embryo
In early development of Xenopus laevis, it is known that activities of polypeptide growth factors are negatively regulated by their binding proteins. In this study, follistatin, originally known as an activin-binding protein, was shown to inhibit all aspects of bone morphogenetic protein (BMP) activity in early Xenopus embryos. Furthermore, using a surface p
The National Academy of Sciences.
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10. Regulation of myostatin activity and muscle growth
Myostatin is a transforming growth factor-β family member that acts as a negative regulator of skeletal muscle mass. To identify possible myostatin inhibitors that may have applications for promoting muscle growth, we investigated the regulation of myostatin signaling. Myostatin protein purified from mammalian cells consisted of a noncovalently held complex
The National Academy of Sciences.
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11. Presence of activin (erythroid differentiation factor) in unfertilized eggs and blastulae of Xenopus laevis.
Activin A, a member of the transforming growth factor beta superfamily, has recently been found to have potent mesoderm-inducing activity on isolated early Xenopus animal-cap cells. We measured the activin activity of the Xenopus egg extract by using an erythroid-differentiating test with Friend leukemia cells. The results showed that an activin homologue is
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12. Activin-A up-regulates type I activin receptor mRNA levels in human immortalized extravillous trophoblast cells.
Activin is known to play an important regulatory role in reproduction, including pregnancy. To further examine the role and signaling mechanism of activin in regulating placental function, the steady-state level of activin type I receptor (ActRI) mRNA in immortalized extravillous trophoblasts (IEVT) cells was measured using competitive PCR (cPCR). An interna
BioMed Central.