And Biological Pharmacological Assays
Mostrando 1-12 de 24 artigos, teses e dissertações.
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1. 4-Phenyl-1,3-thiazole-2-amines as scaffolds for new antileishmanial agents
Abstract Background: There is still a need for new alternatives in pharmacological therapy for neglected diseases, as the drugs available show high toxicity and parenteral administration. That is the case for the treatment of leishmaniasis, particularly to the cutaneous clinical form of the disease. In this study, we present the synthesis and biological scr
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 18/10/2018
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2. Biochemical characterization of a phospholipase A2 homologue from the venom of the social wasp Polybia occidentalis
Abstract Background: Wasp venoms constitute a molecular reservoir of new pharmacological substances such as peptides and proteins, biological property holders, many of which are yet to be identified. Exploring these sources may lead to the discovery of molecules hitherto unknown. This study describes, for the first time in hymenopteran venoms, the identific
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 26/03/2018
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3. In vitro characterization of jellyfish venom fibrin(ogen)olytic enzymes from Nemopilema nomurai
Abstract Background: Because jellyfish are capable of provoking envenomation in humans, they are considered hazardous organisms. Although the effects of their toxins are a matter of concern, information on the venom components, biological activity and pathological mechanisms are still scarce. Therefore, the aim of the present study was to investigate a seri
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 08/02/2018
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4. Antibacterial activity of (-)-cubebin isolated from Piper cubeba and its semisynthetic derivatives against microorganisms that cause endodontic infections
Abstract Recent publications have highlighted the numerous biological activities attributed to the lignan (-)-cubebin (1), Piper cubeba L. f., Piperaceae, and ongoing studies have focused on its structural optimization, in order to obtain derivatives with greater pharmacological potential. The aim of this study was the obtainment of (1), its semisynthetic de
Rev. bras. farmacogn.. Publicado em: 2016-06
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5. Chemical and botanical characterization of Chilean propolis and biological activity on cariogenic bacteria Streptococcus mutans and Streptococcus sobrinus
Propolis is a non-toxic natural substance with multiple pharmacological properties including anticancer, antioxidant, fungicidal, antibacterial, antiviral, and anti-inflammatory among others. The aim of this study was to determine the chemical and botanical characterization of Chilean propolis samples and to evaluate their biological activity against the car
Braz. J. Microbiol.. Publicado em: 2013
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6. Efeito das toxinas purificadas pktx23c3, pktx28c4, pktx20c4, pntx19c1, pntx25a1, pntx37c2, pntx19c2, pntx3-2 na liberação de Glutamato em Sinaptosomas Cérebro Corticais de Rato.
Studies revealed that the venom of the Brazilian armed spider Phoneutria nigriventer contains potent neurotoxins that caused excitatory symptoms such as salivation, lachrymation, priapism, convulsions, flaccid and spastic paralysis. It was also reported that the main mechanism of action of those neurotoxins are effects on ion channels such as inhibition of t
Publicado em: 2010
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7. Efeito da vitamina D no perfil transcricional de cultura organotípica de câncer de mama / Vitamin D effect in the transcriptional profile of breast cancer organotypic culture
High 1,25(OH)2D3 (VD) concentrations (10-100nM) exerts antiproliferative effects and modifies gene expression profile in breast cancer (BC) cell lines. However, studies conducted in cell lines disconsider stromal-epithelium interactions, which are known to regulate breast cancer development. Besides, high VD concentrations may cause hypercalcemia in vivo. Ou
Publicado em: 2010
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8. Propolis effect on streptozotocin-induced diabetic rats
Propolis is one of the hive products that has been used extensively in folk medicine, due to its several biological and pharmacological properties. Besides, propolis-containing products have been intensely marketed by the pharmaceutical industry and health-food stores. This work was carried out in order to investigate whether propolis treatment could revert
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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9. Preparação e avaliação farmacológica de derivados dos lipídios fenólicos do líquido da casca da castanha de caju
The present work describes the utilization of Cashew Nut-Shell Liquid (CNSL), abundant source of phenolic non-isoprenoids lipids from our country, as raw material for preparation of compounds with synthetic applications as well as biological useful. The extraction, separation and characterization of CNSL phenolic nonisoprenoids lipids were done by procedures
Publicado em: 2008
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10. Receptores de hormônios da tireóide: estudos computacionais, ressonância plasmônica de superfície e ensaios celulares / Thyroid hormone receptor: computational studies, surface plasmon resonance and cell based assays
The thyroid hormone receptors (TRs) are transcriptional factors involved in cell differentiation, development, metabolism and physiological function of most tissues. Many lines of evidence show that several pharmacological actions of TRs might be beneficial in medical therapy, specially those mediated by TR that target important medical conditions like obesi
Publicado em: 2008
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11. Anti-carie and antiproliferative effect of 7-epiclusianone, isolated from Rheedia genus plant / Avaliação das atividades anticarie e antiproliferativa da 7-epiclusianona isolada da planta do genero Rheedia
Considering the great use of plants as medicinal substances in the popular medicine, it is critical to investigate their biological and chemical properties in order to not only help to enhance our understanding of the therapeutic potential of these natural products, but also how to make them more effective pharmacological agents. The enormous biodiversitiy o
Publicado em: 2008
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12. Aspectos químicos e fotoquímicos de liberação controlada de óxido nítrico a partir de complexos nitrosilos de rutênio: ensaios farmacológicos e de citotoxicidade. / Chemical and photochemical aspects of control nitric oxide release from nitrosyl ruthenium complexes: pharmacological and cytotoxic assays.
Nitric oxide (NO) is a multipurpose biological agent that shows important role in brain, arteries, immunological system, liver and lungs. The NO basal level alterations have correlation with several diseases as hypertension, cancer, Raymonds disease and platelet aggregation. Aiming supply this deficient NO level, it was necessary propose new compounds that c
Publicado em: 2008