Anti Hypernociception
Mostrando 1-5 de 5 artigos, teses e dissertações.
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1. Polysaccharide rich fractions from barks of Ximenia americana inhibit peripheral inflammatory nociception in mice Antinociceptive effect of Ximenia americana polysaccharide rich fractions
Abstract Ximenia americana L., Olacaceae, barks are utilized in folk medicine as analgesic and anti-inflammatory. The objective was to evaluate the toxicity and antinociceptive effect of polysaccharides rich fractions from X. americana barks. The fractions were obtained by extraction with NaOH, followed by precipitation with ethanol and fractionation by ion
Rev. bras. farmacogn.. Publicado em: 2017-06
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2. CONTRIBUTION TO THE PHARMACOGNOSTIC STUDY OF Polygala cyparissias Saint-Hilaire &Moquin (POLYGALACEAE): CHEMICAL ASPECTS AND EVALUATION OF THE GASTROPROTECTIVE AND ANTI-HYPERNOCICEPTIVE POTENTIAL / CONTRIBUIÇÃO AO ESTUDO FARMACOGNÓSTICO DE Polygala cyparissias Saint-Hilaire &Moquin (POLYGALACEAE): ASPECTOS QUÍMICOS E AVALIAÇÃO DE SEU POTENCIAL GASTROPROTETOR E ANTI-HIPERNOCICEPTIVO
Polygala cyparissias é uma planta popularmente conhecida como pinheiro da praia ou gelol. É etnofarmacologicamente utilizada como analgésico local de aplicação tópica, já tendo sido evidenciada a atividade antinociceptiva da planta. Caracterizase quimicamente pela presença de xantonas. Considerando que tais metabólitos já possuem atividade anti-úl
Publicado em: 2011
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3. Investigation of adenosine endogenous increase decurrent of D-Frutose-1,6-difosfato administration, a glycolytic intermediate. / Investigação do aumento endógeno de adenosina decorrente da administração do intermediário glicolítico D-Frutose-1,6-difosfato
D-Fructose-1,6-bisphosphate (F1,6BP), a high-energy glycolytic pathway intermediate, is reported to have a many pharmacologically effect, but its underlying mechanism of action in inflammation is incompletely understood. In this study, the aim was to examine the function of F1,6BP on cytokines and adenosine. Then, the possible F1,6BP anti-inflammatory activi
Publicado em: 2009
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4. Estudos da inflamação e dor articulares em ratos e dos mecanismos da produção de TNF-a por macrófagos isolados, induzidos pela BaP1, uma metaloproteínase isolada do veneno da serpente Bothrops asper. / Studies on both rat articular inflammation and pain, and mechanisms involved in production of TNF-a by isolated macrophages induced by BaP1, a metalloproteinase isolated from Bothrops asper snake venom.
Metalloproteinases are major enzymes in snake venoms showing high grade of homology with mammal matrix metalloproteinases, present in high levels in inflamed joints. In this study we examined the ability of BaP1, to induce: i) inflammation and hypernociception in rat articular joints and participation of TNF-a and PGE2 in these effects, a
Publicado em: 2008
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5. An electronic pressure-meter nociception paw test for mice
The aim of the present investigation was to describe and validate an electronic mechanical test for quantification of the intensity of inflammatory nociception in mice. The electronic pressure-meter test consists of inducing the animal hindpaw flexion reflex by poking the plantar region with a polypropylene pipette tip adapted to a hand-held force transducer
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-03