Antiandrogens
Mostrando 1-12 de 16 artigos, teses e dissertações.
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1. Morfofisiologia do sistema genital masculino de ratos púberes e adultos após privação androgênica durante a pré-puberdade / Morphophysiology of male reproductive system of adult and pubertal rats after androgen deprivation during prepuberty
Endocrine disrupters are chemicals that can act as agonists or antagonists of endogenous hormones, interfering with the homeostasis of the organism. Since the endocrine system plays a critical role in the development and function of the male reproductive system, this is an especially vulnerable target of potential endocrine perturbations. The literature pres
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/02/2012
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2. The seven-year preliminary results of brachytherapy with Iodine-125 seeds for localized prostate cancer treated at a Brazilian single-center
OBJECTIVE: To report the seven-year preliminary results of a single-center on brachytherapy with Iodine-125 seeds, used in combination with external beam radiotherapy in selected patients with localized prostate cancer (T1-T2). MATERIALS AND METHODS: All 105 patients treated by brachytherapy with Iodine-125 seeds, from January/1998 to December/2004, were ret
International braz j urol. Publicado em: 2007-12
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3. Androgen receptors expression in the Mongolian gerbil ventral prostate / Expressão de receptores androgenicos no lobulo ventral da prostata do gerbilo da Mongolia
The normal growth, differentiation and maintenance of the morphofunctional integrity of the prostate gland are dependent on the interaction of constant levels of androgens with their receptors. The need to study the responses to hormones under several conditions and the effect of their blockage is due to the fact that the human prostate is the site of a grea
Publicado em: 2007
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4. A prostata ventral do gerbilo frente as diferentes formas de castração e subsequente reposição hormonal pela testosterona
The prostate is an exocrine gland of the male genital system, which secretes part of seminal liquidolts differentiation initiates in the beginning of the embryonic development and finishes during the puberty. Testosterone (T) plays an essential role in prostate maintenance, after transformation, by 5a-reductase enzyme, to dehidrotestostorone (DHT) an more po
Publicado em: 2005
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5. Promotion of agonist activity of antiandrogens by the androgen receptor coactivator, ARA70, in human prostate cancer DU145 cells
Although hormone therapy with antiandrogens has been widely used for the treatment of prostate cancer, some antiandrogens may act as androgen receptor (AR) agonists that may result in antiandrogen withdrawal syndrome. The molecular mechanism of this agonist response, however, remains unclear. Using mammalian two-hybrid assay, we report that antiandrogens, hy
The National Academy of Sciences.
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6. Inactivation of androgen receptor coregulator ARA55 inhibits androgen receptor activity and agonist effect of antiandrogens in prostate cancer cells
Antiandrogens given to antagonize androgen receptor (AR) activity gradually lose their efficacy as antagonists and eventually function as agonists to promote (instead of block) AR-mediated growth of prostate cancer cells. The mechanisms of how antiandrogens acquire this agonist activity during hormonal therapy are largely unknown. Here, we report that expres
The National Academy of Sciences.
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7. Effects of Androgen Treatment on Expression of Macrophage Fcγ Receptors
Macrophage Fcγ receptors (FcγRs) play an important role in the host defense against infection and in the pathophysiology of immune cytopenias. Modulation of macrophage FcγR expression is a potential therapeutic approach to immune disorders. Glucocorticoids and progesterones decrease macrophage FcγR expression. We assessed the effect of treatment with and
American Society for Microbiology.
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8. ACP Broadsheet 131: March 1992. Hirsute women: should they be investigated?
Should hirsute women be investigated? Most only need careful clinical evaluation. First, they need to be examined to determine whether they are hirsute or hypertrichotic, and for the degree of hair growth to assess the most appropriate form of treatment. Second, they need to be clinically evaluated for signs and symptoms of virilism to determine the extent o
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9. 3β-Acetoxyandrost-1,5-diene-17-ethylene ketal functions as a potent antiandrogen with marginal agonist activity
The majority of available antiandrogens have been reported to possess agonist activity to induce prostate-specific antigen, which might result in antiandrogen withdrawal syndrome. Here we report the identification of 3β-acetoxyandrost-1,5-diene-17-ethylene ketal (ADEK) from dehydroepiandrosterone metabolites and derivatives as a potent antiandrogen. We foun
The National Academy of Sciences.
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10. Hormonal therapy for stage D cancer of the prostate.
Adenocarcinoma of the prostate is the most common malignant neoplasm occurring in men. About half of patients present with metastatic disease. The mainstay of the treatment of stage D cancer of the prostate is hormonal therapy. Bilateral simple orchiectomy remains the gold standard with which other therapies must be compared. Luteinizing hormone-releasing ho
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11. Simultaneous administration of pure antiandrogens, a combination necessary for the use of luteinizing hormone-releasing hormone agonists in the treatment of prostate cancer.
Although castration levels of serum androgens are consistently achieved after 2-3 weeks of treatment with luteinizing hormone-releasing hormone (LHRH) agonists, the administration of these peptides alone in adult men is always accompanied by a transient increase in plasma testosterone and dihydrotestosterone levels, which lasts for 5-15 days at the beginning
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12. Steroid-induced androgen receptor–oestradiol receptor β–Src complex triggers prostate cancer cell proliferation
Treatment of human prostate carcinoma-derived LNCaP cells with androgen or oestradiol triggers simultaneous association of androgen receptor and oestradiol receptor β with Src, activates the Src/Raf-1/Erk-2 pathway and stimulates cell proliferation. Surprisingly, either androgen or oestradiol action on each of these steps is inhibited by both anti-androgens
Oxford University Press.