Antiangiogenic Activity
Mostrando 1-12 de 57 artigos, teses e dissertações.
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1. Antitumor activity of irinotecan with ellagic acid in C6 glioma cells
SUMMARY OBJECTIVE: Irinotecan-based combination chemotherapies in malignant gliomas need to be examined. The aim of this study was to investigate the synergetic effect of ellagic acid, a natural polyphenolic antioxidant compound, with irinotecan, an inhibitor of topoisomerase I enzyme, on the growth, cadherin switch, and angiogenic processes of a glioma cel
Revista da Associação Médica Brasileira. Publicado em: 2022
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2. Importance of the putative furin recognition site 742RNRR745 for antiangiogenic Sema3C activity in vitro
Angiogenesis is one of the key processes in the growth and development of tumors. Class-3 semaphorins (Sema3) are characterized as axon guidance factors involved in tumor angiogenesis by interacting with the vascular endothelial growth factor signaling pathway. Sema3 proteins convey their regulatory signals by binding to neuropilins and plexins receptors, wh
Braz J Med Biol Res. Publicado em: 08/10/2018
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3. Anti-angiogenic activity of iridoids from Galium tunetanum
ABSTRACT The phytochemical study of Galium tunetanum Lam., Rubiaceae, leaves led to the isolation of 13 compounds from the chloroform–methanol and the methanol extracts, including six iridoid glycosides, one non-glycoside iridoid, two p-coumaroyl iridoid glycosides, two phenolic acids, and two flavonoid glycosides. The structural determination of the isola
Rev. bras. farmacogn.. Publicado em: 2018-06
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4. Alternagin-C binding to α2β1 integrin controls matrix metalloprotease-9 and matrix metalloprotease-2 in breast tumor cells and endothelial cells
Abstract Background Matrix metalloproteinases (MMPs) are key players in tumor progression, helping tumor cells to modify their microenvironment, which allows cell migration to secondary sites. The role of integrins, adhesion receptors that connect cells to the extracellular matrix, in MMP expression and activity has been previously suggested. However, the m
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 24/05/2018
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5. Complexos metálicos de hidrazonas, tiossemicarbazonas e lapachol: atividade farmacológica e avaliação de relações estrutura-atividade
The present work comprises the synthesis and characterization of metal compounds with bioactive ligands and the study of their pharmacological profile. Anti-inflammatory, antimicrobial, antiparasitic and antitumor drug candidates were designed. Complex [Zn(LASSBio-466)H2O]2 was synthesized with salicylaldehyde-2-chlorobenzoyl hydrazone (H2LASSBio-466), while
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 10/02/2012
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6. Estudo do papel biológico da enzima ácido graxo sintase (FASN) em células endoteliais derivadas dos vasos sanguíneos / Study of the biological role of the enzyme fatty acid synthase (FASN) in endothelial cells derived from blood vessels
Fatty acid synthase (FASN) is the anabolic enzyme with high expression and activity in several human malignancies, which is responsible for the endogenous synthesis of saturated fatty acids and consequently of the phospholipids present in cell membranes. Inhibition of FASN with orlistat (Xenical), an anti-obesity drug, is described as having anti-neoplastic
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2011
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7. AvaliaÃÃo do potencial antitumoral e antiangiogÃnico de novos anÃlogos ftalimÃdicos da talidomida / EVALUATION OF THE ANTITUMOR AND ANTIANGIOGENIC POTENTIAL OF NEW FTHALIMIDES THALIDOMIDE ANALOGUES
The thalidomide was previously used to relieve gastric discomforts during pregnancy, and currently it is used for cancer treatment and inflammatory illnesses. Various phthalimides analogues of thalidomide have been researched for its antiangiogenic and immunemodulatory activity. In previous studies, these analogues showed absence of immunesuppressor activity
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 09/12/2011
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8. Atividade anti-angiogênica e modulação das proteínas envolvidas na neoformação vascular por compostos bioativos da própolis / Anti-angiogenic activity and modulation of protein-involved in new vases formation by propolis bioactive compounds
Propolis is rich in bioactive compounds and widely used in alternative medicine as a preventive agent and/or in therapy. We evaluate the impact of polyphenol-rich fractions of propolis from different origins and types in the angiogenesis process in atherosclerotic lesions. The following samples of propolis were used: Red (red, Alagoas, Brazil), Green (green,
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/07/2011
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9. Investigação da mielotoxicidade e do potencial indutor de morte celular de Synadenium umbellatum Pax. em células do tumor ascítico de Ehrlich / Investigation of myelotoxicity and potential inducer cell death of Synadenium umbellatum Pax. cell Ehrlich ascites tumor
In search of new antineoplasic agents natural products have played an important role, given that about 40% of available medicines in current treatments have been developed from natural sources, 25% approximately of plants. Synadenium umbellatum belongs to Euphorbiaceae family and is popularly known as "cola-nota", "avelós," "milagrosa", "cancerola", and the
Publicado em: 2010
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10. Collagen XVIII/endostatin expression in experimental endotoxemic acute renal failure
Acute renal failure (ARF) is a frequent complication of Gram-negative sepsis, with a high risk of mortality. Lipopolysaccharide (LPS)-induced ARF is associated with hemodynamic changes that are strongly influenced by the overproduction of nitric oxide (NO) through the cytokine-mediated up-regulation of inducible NO synthase. LPS-induced reductions in systemi
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-12
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11. Quantificação de células endoteliais circulantes em portadores assintomáticos do vírus linfotrópico humano de células T do tipo 1 (HTLV1) por citometria de fluxo / Quantification of circulating endothelial cells in human T cell lymphotropic virus type 1 (HTLV1) asymptomatic carriers by flow cytometry
Endothelial cells originated from the bone marrow (BM) take part in the physiopathology of several diseases which have vascular damage as a common factor. In spite of being a rare event, they are found in augmented quantity in the peripheral circulation of cancer patients. Evidence indicates that bone marrow-derived endothelial progenitor cells (CEPs) can co
Publicado em: 2009
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12. Análise química e taxonômica de espécies de hypericum e avaliação da atividade antiangiogênica / Chemical and taxonomic analysis of Hypericum species and antiangiogenic activity
A comercialização de fitoterápicos obtidos a partir de extratos de H. perforatum para o tratamento de depressão em diversas partes do mundo despertou o interesse de investigadores no estudo de plantas do gênero Hypericum, tanto acerca da composição química quanto das propriedades biológicas destas espécies. Objetivos: Investigar a constituição qu
Publicado em: 2007