Antigen Diversity
Mostrando 1-12 de 296 artigos, teses e dissertações.
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1. Variability in the virulence of specific Mycobacterium tuberculosis clinical isolates alters the capacity of human dendritic cells to signal for T cells
BACKGROUND Once in the pulmonary alveoli, Mycobacterium tuberculosis (Mtb) enters into contact with alveolar macrophages and dendritic cells (DCs). DCs represent the link between the innate and adaptive immune system owing to their capacity to be both a sentinel and an orchestrator of the antigen-specific immune responses against Mtb. The effect that the v
Mem. Inst. Oswaldo Cruz. Publicado em: 12/08/2019
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2. Determination of an unrelated donor pool size for human leukocyte antigen-matched platelets in Brazil
ABSTRACT Background: Successful transfusion of platelet refractory patients is a challenge. Many potential donors are needed to sustain human leukocyte antigen matched-platelet transfusion programs because of the different types of antigens and the constant needs of these patients. For a highly mixed population such as the Brazilian population, the pool siz
Rev. Bras. Hematol. Hemoter.. Publicado em: 2016-02
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3. Cryptic species of Paracoccidioides brasiliensis: impact on paracoccidioidomycosis immunodiagnosis
We aimed to evaluate whether the occurrence of cryptic species of Paracoccidioides brasiliensis, S1, PS2, PS3 and Paracoccidioides lutzii, has implications in the immunodiagnosis of paracoccidioidomycosis (PCM). Small quantities of the antigen gp43 were found in culture filtrates of P. lutzii strains and this molecule appeared to be more variable within P. l
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-08
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4. Genetic polymorphisms in the glutamate-rich protein of Plasmodium falciparum field isolates from a malaria-endemic area of Brazil
The genetic diversity displayed by Plasmodium falciparum, the most deadly Plasmodium species, is a significant obstacle for effective malaria vaccine development. In this study, we identified genetic polymorphisms in P. falciparum glutamate-rich protein (GLURP), which is currently being tested in clinical trials as a malaria vaccine candidate, from isolates
Mem. Inst. Oswaldo Cruz. Publicado em: 2013-06
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5. Molecular markers and genetic diversity of Plasmodium vivax
Enhanced understanding of the transmission dynamics and population genetics for Plasmodium vivax is crucial in predicting the emergence and spread of novel parasite phenotypes with major public health implications, such as new relapsing patterns, drug resistance and increased virulence. Suitable molecular markers are required for these population genetic stu
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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6. Redundancy and recombination in the Echinococcus AgB multigene family : is there any similarity with protozoan contigency genes?
Numerous genetic variants of the Echinococcus antigen B (AgB) are encountered within a single metacestode. This could be a reflection of gene redundancy or the result of a somatic hypermutation process. We evaluate the complexity of the AgB multigene family by characterizing the upstream promoter regions of the 4 already known genes (EgAgB1-EgAgB4) and evalu
Publicado em: 2011
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7. Reduced genetic variability within coding and non-coding regions of the echinococcus multilocularis genome
Echinococcus multilocularis, a vulpine intestinal tapeworm, is the causative agent of alveolar echinococosis in humans, one of the most severe and lethal parasitic infections in man. To date, there is very little knowledge about the genetical polymorphism of this parasite. To assess sequence polymorphism, we analysed a sample of 33 E. multilocularis isolates
Publicado em: 2011
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8. Mosquito Anthropophily: implications on malaria transmission in the northern Brazilian Amazon
Seasonal variation of adults and larvae of anophelines was studied during 2003 and 2004 in Roraima State, located in the Northern region of Brazilian Amazon. Species diversity increased with distance of capture to human dwellings. Greater diversity was found in extradomiciliary collections than in peridomiciliary or intradomiciliary. A significant associatio
Neotropical Entomology. Publicado em: 2010-12
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9. Generation of diversity in Streptococcus mutans genes demonstrated by MLST
Streptococcus mutans, consisting of serotypes c, e, f and k, is an oral aciduric organism associated with the initiation and progression of dental caries. A total of 135 independent Streptococcus mutans strains from caries-free and caries-active subjects isolated from various geographical locations were examined in two versions of an MLST scheme consisting o
Publicado em: 2010
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10. Demography, genetic diversity, and population relationships among Argentinean Mapuche Indians
Fertility, mortality and migration data from four Mapuche Indian communities located along a 215-km NE-SW linear area in the Province of Río Negro, Argentina, were collated with genetic information furnished by nine blood group systems and by mtDNA haplogroups. The demographic and genetic data indicated a clear dichotomy, which split the four populations in
Publicado em: 2010
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11. Dimorfismo alélico na proteína de superfície MSP-6 de merozoítos de Plasmodium falciparum. / Allelic dimorphism in Plasmodium falciparum merozoite surface protein-6 (MSP-6).
The development of a vaccine against malaria caused by Plasmodium falciparum has been hampered by the high level of antigen polymorphism exhibited by this parasite. Allelic dimorphism is a pattern in which every observed allele of a gene is clearly grouped into one of two families. The dimorphic protein MSP-6 forms a complex with MSP-1 (also dimorphic) on me
Publicado em: 2008
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12. Marcadores microssatélites no mhc de ovinos : estudos de associação e diversidade genética na raça Santa Inês
The objective of this study was to verify the existence of significant associations between alleles of the ovine MHC (OLA - ovine leucocyte antigen) with characteristics of performance, carcass and resistance to gastrointestinal parasites in purebred Santa Inês sheep and their crosses with Bergamasca, Texel and Ile de France sires from different localities.
Publicado em: 2007