Antitumour
Mostrando 1-12 de 81 artigos, teses e dissertações.
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1. In vitro anticancer and antioxidant potential of Amaranthus cruentus protein and its hydrolysates
Abstract New insights on the use of peptides as therapeutic agents in the treatment of cancer have emerged with reports showing anti-tumour activity of peptides, predominantly derived from animals or microorganisms. Amaranth is a pseudocereal traditionally acknowledged to possess pharmacotherapeutic properties. Thus, the aim of this study was to compare the
Food Sci. Technol. Publicado em: 2020-12
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2. Bioactive endophytic fungi isolated from Caesalpinia echinata Lam. (Brazilwood) and identification of beauvericin as a trypanocidal metabolite from Fusarium sp.
Aiming to identify new sources of bioactive secondary metabolites, we isolated 82 endophytic fungi from stems and barks of the native Brazilian tree Caesalpinia echinata Lam. (Fabaceae). We tested their ethyl acetate extracts in several in vitro assays. The organic extracts from three isolates showed antibacterial activity against Staphylococcus aureus and E
Mem. Inst. Oswaldo Cruz. Publicado em: 16/01/2015
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3. Ouratea genus: chemical and pharmacological aspects
Ouratea and the other genera of the Ochnaceae family are a rich source of flavonoids and biflavonoids. These can be used as chemotaxonomic markers of Ouratea. Some biflavonoids, as well as extracts of the Ouratea species show important biological activities, such as antitumour, antiviral, vasodilation, antimicrobial and DNA topoisomerase inhibition. On the
Rev. bras. farmacogn.. Publicado em: 2014-01
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4. Derivados oleananos e ursanos e sua importância na descoberta de novos fármacos com atividade antitumoral, anti-inflamatória e antioxidante
Oleanolic and ursolic acids are triterpenes that exist abundantly in the plant kingdom. They show antitumor activity and their cytotoxic activity was already evaluated against a broad range of cell lines. The inhibition of enzymes involved in the metabolism of DNA and the induction of apoptosis are known events that have been related to the antitumour activi
Química Nova. Publicado em: 2009
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5. 2-Acylcyclohexane-1,3-diones from Peperomia trineura (Miq.) / 2-Acil-cicloexano-1,3-dionas de Peperomia trineura (Miq.)
The crude extract of whole plant (Peperomia trineura) was subjected to adsorption chromatography on silica gel, preparative thin-layer chromatography (CCDP) and semi-preparative HPLC, resulting in the isolation of five novel polyketides with variable chain lenght or presence of unsaturation in the alkyl chain. The structural elucidation of these compounds wa
Publicado em: 2009
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6. Genetic diversity analysis by MLSA and antitumoral activity evaluation of Chromobacterium sp. strains. / Análise da diversidade genética por MLSA e avaliação da atividade antitumoral de linhagens de Chromobacterium sp.
A diversidade genética dos isolados de Chromobacterium sp. foi avaliada por Multilocus sequence analysis com base nas análises dos genes conservados rpoA, lepA, gyrB, fusA e rRNA 16S. A análise do gene rRNA 16S e MLSA agrupou os isolados no gênero Chromobacterium, entretanto, cinco dos isolados estão distantes filogeneticamente das linhagens tipo, C. vi
Publicado em: 2009
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7. Perfil FarmacolÃgico e ToxicolÃgico de Produtos Bioativos Obtidos de Streptomyces spp Isolados do Leito de Rios do Estado da ParaÃba
Aimed to search for species of Streptomyces isolated from mesoregions of Paraiba producers of bioactive metabolites with pharmacological activity, assessing the levels of toxicity of extracts and their chemical composition. 49 species of the genus Streptomyces were isolated from 68 samples of soil bed in the main rivers in different mesoregiÃes the state of
Publicado em: 2009
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8. Estudo das atividades citotÃxica e antitumoral de vitafisilinas isoladas de Acnistus Arborescens. / Study of cytotoxic and antitumour activities of withaphysalins isolated from Acnistus arborescens.
As vitafisalinas sÃo lactonas esteroidais (C28), estruturalmente baseadas no esqueleto do ergostano, comumente encontradas em plantas da famÃlia Solanaceae. A fim de avaliar as propriedades anticÃncer desses compostos, cinco vitafisalinas [O, F, M, N e (17S, 20R, 22R) -5 β, 6β :18,20-2-diepÃxi β-4, 18 - diidrÃxi-1 - oxovita-3-24-enolido]
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 14/07/2008
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9. Estudo cristaloquímico de quatro derivados fenazínicos utilizando a difração de raios-X.
In general, natural and synthetic phenazines have attracted much attention because of their biological activities, like antitumour agents antimalarials, antibiotics, among others. The natural phenazines are isolated as secondary metabolites of terrestrial and marine microorganisms, mainly of Pseudomonas spp. and Streptomyces spp. This work aiming the structu
Publicado em: 2008
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10. Estudo fitoquÃmico e biolÃgico da hyptis mutabilis salz:(lamiaceae) / Phytochemistry and biological study of hyptis mutabilis
Crude extract of different parts of Hyptis mutabilis obtained using solvent of different polarities were submitted to the anti-microbial screening against 21 microorganisms from Departmental collection and clinically isolated to select the one with largest activity for phytochemistry studies. For MIC determination the extracts that presented halos above 14 m
Publicado em: 2003
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11. ObtenÃÃo, caracterizaÃÃo e avaliaÃÃo microbiolÃgica de uma nova forma farmacÃutica contendo hidroquinona
Hydroquinone (HQ) is a drug reported to possess manifold biological activities, such as depigmenting, antimicrobial and antitumour properties. The PluronicLecithin Organogel (PLOme) is a phospholipidic microemulsion particularly implied when a high cutaneous permeability and systemic absorption of a drug is suitable. Once that HQ is highly unstable i
Publicado em: 2003
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12. Cytotoxic and Antiviral Activities of Colombian Medicinal Plant Extracts of the Euphorbia genus
Forty-seven plant extracts of 10 species of the genus Euphorbia (Euphorbiaceae) used by Colombian traditional healers for the treatment of ulcers, cancers, tumors, warts, and other diseases, were tested in vitro for their potential antitumour (antiproliferative and cytotoxic) and antiherpetic activity. To evaluate the capacity of the extracts to inhibit the
Memórias do Instituto Oswaldo Cruz. Publicado em: 2002-06