Apicoplast
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Isoprenoid biosynthesis in the erythrocytic stages of Plasmodium falciparum
The development of new drugs is one strategy for malaria control. Biochemical pathways localised in the apicoplast of the parasite, such as the synthesis of isoprenic precursors, are excellent targets because they are different or absent in the human host. Isoprenoids are a large and highly diverse group of natural products with many functions and their synt
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-08
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2. Filogenia molecular de protozoários pertencentes à sub-família Toxoplasmatinae pela análise de genes mitocondriais e de apicoplasto / Molecular phylogeny in protozoan of the subfamily toxoplasmatinae based on genes of mitocôndria and apicoplasto
Os membros da sub-família Toxoplasmatinae conhecidos são Hammondia hammondi, Toxoplasma gondii, Neospora hughesi, Neospora caninum, Hammondia heydorni e Besnoitia spp. Os cães (e provavelmente outras espécies de canídeos) são hospedeiros definitivos de N. caninum e H. heydorni. Os oocistos destas espécies de coccídios são morfologicamente indistingu
Publicado em: 2010
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3. Protein trafficking to the plastid of Plasmodium falciparum is via the secretory pathway
The plastid of Plasmodium falciparum (or ‘apicoplast’) is the evolutionary homolog of the plant chloroplast and represents a vestige of a photosynthetic past. Apicoplast indispensability indicates that it still provides essential functions to parasites. Similar to plant chloroplasts, the apicoplast is dependent on many nucleus-encoded genes to provide th
Oxford University Press.
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4. Genetic Evidence that an Endosymbiont-derived Endoplasmic Reticulum-associated Protein Degradation (ERAD) System Functions in Import of Apicoplast Proteins*
Most apicomplexan parasites harbor a relict chloroplast, the apicoplast, that is critical for their survival. Whereas the apicoplast maintains a small genome, the bulk of its proteins are nuclear encoded and imported into the organelle. Several models have been proposed to explain how proteins might cross the four membranes that surround the apicoplast; howe
American Society for Biochemistry and Molecular Biology.
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5. Nuclear-encoded proteins target to the plastid in Toxoplasma gondii and Plasmodium falciparum
A vestigial, nonphotosynthetic plastid has been identified recently in protozoan parasites of the phylum Apicomplexa. The apicomplexan plastid, or “apicoplast,” is indispensable, but the complete sequence of both the Plasmodium falciparum and Toxoplasma gondii apicoplast genomes has offered no clue as to what essential metabolic function(s) this organell
The National Academy of Sciences.
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6. Multiple Functionally Redundant Signals Mediate Targeting to the Apicoplast in the Apicomplexan Parasite Toxoplasma gondii
Most species of the protozoan phylum Apicomplexa harbor an endosymbiotic organelle—the apicoplast—acquired when an ancestral parasite engulfed a eukaryotic plastid-containing alga. Several hundred proteins are encoded in the parasite nucleus and are posttranslationally targeted to the apicoplast by a distinctive bipartite signal. The N-terminal 20 to 30
American Society for Microbiology.
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7. A plastid segregation defect in the protozoan parasite Toxoplasma gondii
Apicomplexan parasites—including the causative agents of malaria (Plasmodium sp.) and toxoplasmosis (Toxoplasma gondii)—harbor a secondary endosymbiotic plastid, acquired by lateral genetic transfer from a eukaryotic alga. The apicoplast has attracted considerable attention, both as an evolutionary novelty and as a potential target for chemotherapy. We r
Oxford University Press.
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8. Subcellular localization of acetyl-CoA carboxylase in the apicomplexan parasite Toxoplasma gondii
Apicomplexan parasites such as Toxoplasma gondii contain a primitive plastid, the apicoplast, whose genome consists of a 35-kb circular DNA related to the plastid DNA of plants. Plants synthesize fatty acids in their plastids. The first committed step in fatty acid synthesis is catalyzed by acetyl-CoA carboxylase (ACC). This enzyme is encoded in the nuc
The National Academy of Sciences.
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9. Multiple Metabolic Roles for the Nonphotosynthetic Plastid of the Green Alga Prototheca wickerhamii†
The presence of plastids in diverse eukaryotic lineages that have lost the capacity for photosynthesis is well documented. The metabolic functions of such organelles, however, are poorly understood except in the case of the apicoplast in the Apicomplexa, a group of intracellular parasites including Plasmodium falciparum, and the plastid of the green alga Hel
American Society for Microbiology.
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10. Dynamics of Toxoplasma gondii Differentiation†
Parasite differentiation is commonly associated with transitions between complex life cycle stages and with long-term persistence in the host, and it is therefore critical for pathogenesis. In the protozoan parasite Toxoplasma gondii, interconversion between rapidly growing tachyzoites and latent encysted bradyzoites is accompanied by numerous morphological
American Society for Microbiology.
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11. A Type II Pathway for Fatty Acid Biosynthesis Presents Drug Targets in Plasmodium falciparum
It has long been held that the malaria parasite, Plasmodium sp., is incapable of de novo fatty acid synthesis. This view has recently been overturned with the emergence of data for the presence of a fatty acid biosynthetic pathway in the relict plastid of P. falciparum (known as the apicoplast). This pathway represents the type II pathway common to plant chl
American Society for Microbiology.
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12. Chloroplast transit peptide prediction: a peek inside the black box
Previous work in predicting protein localization to the chloroplast organelle in plants led to the development of an artificial neural network-based approach capable of remarkable accuracy in its prediction (ChloroP). A common criticism against such neural network models is that it is difficult to interpret the criteria that are used in making prediction
Oxford University Press.