2-Acylcyclohexane-1,3-diones from Peperomia trineura (Miq.) / 2-Acil-cicloexano-1,3-dionas de Peperomia trineura (Miq.)

AUTOR(ES)

Edgard Antonio Ferreira

DATA DE PUBLICAÇÃO

2009

RESUMO

The crude extract of whole plant (Peperomia trineura) was subjected to adsorption chromatography on silica gel, preparative thin-layer chromatography (CCDP) and semi-preparative HPLC, resulting in the isolation of five novel polyketides with variable chain lenght or presence of unsaturation in the alkyl chain. The structural elucidation of these compounds was based on spectroscopic techniques for 1D and 2D NMR, infrared and low and high resolution mass spectrometry. The fractions from the crude extract were tested against the two leukemic cell lines (K-562 and Nalm 6), showing considerable activities. The polyketides were evaluated against the phytopathogenic fungi - Cladosporium cladosporioides and C. sphaerospermum - and displayed low and medium activity.

ASSUNTO(S)

antifúngicos (avaliação; atividade) antitumoral organic chemistry produtos naturais medicinal plants natural products peperomia trineura peperomia trineura química orgânica polyketides plantas medicinais policetídeos piperaceae antitumour antifungal piperaceae

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