A bacteriocin of Actinobacillus actinomycetemcomitans.
AUTOR(ES)
Hammond, B F
RESUMO
An inhibitory factor from Actinobacillus actinomycetemcomitans Y4 was isolated, and its properties indicated that it was a bacteriocin (actinobacillicin). The bacteriocin was active against Streptococcus sanguis strains, Streptococcus uberis (FDC1), and Actinomyces viscosus T14 as well as other strains of A. actinomycetemcomitans, but not against other crevicular bacteria, including other streptococci and actinomycetes. The activity of this bacteriocin was inhibited by pronase, trypsin, and heat (45 min at 56 degrees C) but not by DNase, RNase, phospholipase, exposure to UV light, or low pH (1.0 to 6.5). Although actinobacillicin markedly inhibited glycolysis in S. sanguis, the primary mechanism of its bactericidal action appears to be alterations in cell permeability, with the resultant leakage of RNA, DNA, and other essential intracellular macromolecules. These findings provide an ecologic explanation for the reciprocal growth relationship between A. actinomycetemcomitans and S. sanguis/Actinomyces viscosus observed in localized juvenile periodontitis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=260394Documentos Relacionados
- Purification and biochemical properties of a bacteriocin from Actinobacillus actinomycetemcomitans.
- Monoclonal antibodies to Actinobacillus actinomycetemcomitans.
- Endocarditis caused by Actinobacillus actinomycetemcomitans.
- Monoclonal antibodies to leukotoxin of Actinobacillus actinomycetemcomitans.
- In vitro antimicrobial susceptibility of Actinobacillus actinomycetemcomitans.
