A dosage-sensitive modifier of retrotransposon-induced alleles of the Drosophila white locus.
AUTOR(ES)
Rabinow, L
RESUMO
The apricot allele of the white locus results from the insertion of the retrotransposon copia. Mutations in a newly discovered locus, the Darkener-of-apricot (Doa), suppress wa and some of its revertants. Of 44 other white alleles tested, only wsp55 is affected by Doa, although, in contrast, it is enhanced by Doa mutations. The Doa locus modulates wa and wsp55 expression as a function of its own dosage. Mutations in Doa are dominant suppressors or enhancers and are recessive lethals. Rare Doa mutant homozygotes escaping lethality demonstrate extreme phenotypic suppression of wa and enhancement of wsp55. RNA from wa is substantially wild-type in structure in escapers, although reduced in quantity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=400888Documentos Relacionados
- Dosage-Sensitive Maternal Modifiers of the Drosophila Segmentation Gene Runt
- The Meiotic Effects of a Deficiency in DROSOPHILA MELANOGASTER: Identification of Two Dosage-Sensitive Sites
- Retrotransposon-Induced Ectopic Expression of Cut Causes the Om(1a) Mutant in Drosophila Ananassae
- Retrotransposon-induced overexpression of a homeobox gene causes defects in eye morphogenesis in Drosophila.
- Dosage-sensitive requirement for mouse Dll4 in artery development