A gratuitous inducer of cat-86, amicetin, inhibits bacterial peptidyl transferase.
AUTOR(ES)
Gu, Z
RESUMO
Expression of the chloramphenicol resistance gene cat-86 is regulated by translation attenuation. Among the three ribosomally targeted antibiotics that can induce the gene, only amicetin has an unknown mode of action. Here we demonstrate that the nucleoside antibiotic amicetin is an inhibitor of bacterial peptidyl transferase. Thus, the three inducers of cat-86, chloramphenicol, erythromycin, and amicetin, interact with the peptidyl transferase region of bacterial ribosomes.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=177074Documentos Relacionados
- Site in the cat-86 regulatory leader that permits amicetin to induce expression of the gene.
- Polysome Metabolism in Escherichia coli: Amicetin, an Antibiotic That Stabilizes Polysomes1
- Induction of the chloramphenicol acetyltransferase gene cat-86 through the action of the ribosomal antibiotic amicetin: involvement of a Bacillus subtilis ribosomal component in cat induction.
- Peptidyl transferase inhibition by the nascent leader peptide of an inducible cat gene.
- Analysis of the regulatory sequences needed for induction of the chloramphenicol acetyltransferase gene cat-86 by chloramphenicol and amicetin.
