A Large Cluster of Highly Expressed Genes Is Dispensable for Growth and Development in Aspergillus Nidulans

AUTOR(ES)

Aramayo, R.

RESUMO

We investigated the functions of the highly expressed, sporulation-specific SpoC1 genes of Aspergillus nidulans by deleting the entire 38-kb SpoC1 gene cluster. The resultant mutant strain did not differ from the wild type in (1) growth rate, (2) morphology of specialized reproductive structures formed during completion of the asexual or sexual life cycles, (3) sporulation efficiency, (4) spore viability or (5) spore resistance to environmental stress. Thus, deletion of the SpoC1 gene cluster, representing 0.15% of the A. nidulans genome, had no readily detectable phenotypic effects. Implications of this result are discussed in the context of major alterations in gene expression that occur during A. nidulans development.

Documentos Relacionados

• Capn5 Is Expressed in a Subset of T Cells and Is Dispensable for Development
• The Expression of Sterigmatocystin and Penicillin Genes in Aspergillus nidulans Is Controlled by veA, a Gene Required for Sexual Development
• Mek2 Is Dispensable for Mouse Growth and Development
• Matrilin-3 Is Dispensable for Mouse Skeletal Growth and Development
• Codon usage in yeast: cluster analysis clearly differentiates highly and lowly expressed genes.