A large pool of releasable vesicles in a cortical glutamatergic synapse
AUTOR(ES)
Hallermann, Stefan
FONTE
National Academy of Sciences
RESUMO
To probe exocytosis at a cortical glutamatergic synapse, we made capacitance measurements in whole-cell recorded hippocampal mossy fiber terminals. Evaluation of different methods by using a morphology-based equivalent electrical model revealed that quantitative capacitance measurements are possible in this presynaptic structure. Voltage pulses leading to presynaptic Ca2+ inflow evoked large capacitance signals that showed saturation with increasing pulse duration. The mean peak capacitance increase was 100 fF, corresponding to a pool of ≈1,400 releasable vesicles. Thus hippocampal mossy fiber synapses have a vesicular “maxipool.” Large pool size and rapid vesicle recycling may underlie the uniquely large extent of activity-dependent plasticity in this synapse.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=166423Documentos Relacionados
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