A mechanism for RNA splicing.
AUTOR(ES)
Rogers, J
RESUMO
The most abundant of the stable small nuclear RNAs of eukaryotic cells, U-1 small nuclear RNA, is exactly complementary to the consensus sequences at RNA splice sites. We propose that this RNA is the recognition component of the nuclear RNA splicing enzyme and forms base pairs with both ends of an intron so as to align them for cutting and splicing.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=348611Documentos Relacionados
- Mechanism for cryptic splice site activation during pre-mRNA splicing.
- Evidence for a role for galectin-1 in pre-mRNA splicing.
- Evidence against a scanning model of RNA splicing.
- Phosphorothioate substitution identifies phosphate groups important for pre-mRNA splicing.
- UACUAAC is the preferred branch site for mammalian mRNA splicing.