A novel pathway for transversion mutation induced by dCTP misincorporation in a mutator strain of CHO cells.
AUTOR(ES)
Phear, G
RESUMO
Intracellular imbalances of dCTP produce both T----C transitions and an unusual class of transversions (A----C) at the aprt locus of CHO cells. Our data suggest that this transversion pathway is the consequence of dCTP:T mispairs which are not efficiently proofread during DNA replication.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=362603Documentos Relacionados
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