A possible role for the yeast TATA-element-binding protein in DNA replication.
AUTOR(ES)
Lue, N F
RESUMO
The TATA-element-binding protein (TBP) is involved in the initiation of transcription by all three eukaryotic RNA polymerases. The following observations implicate TBP in the initiation of DNA replication at yeast chromosomal origins as well: (i) Recombinant yeast TBP binds specifically to functionally important regions of many yeast replication origins in vitro. (ii) TBP-binding sites from RNA polymerase II promoters can activate defective replication origins in vivo. (iii) Point mutations in TBP-binding sites that diminish their affinity for TBP in vitro reduce their ability to support replication in vivo.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=47279Documentos Relacionados
- A role for the yeast SWI/SNF complex in DNA replication.
- Double-strand break repair in the absence of RAD51 in yeast: a possible role for break-induced DNA replication.
- Saturation mutagenesis of a yeast his3 "TATA element": genetic evidence for a specific TATA-binding protein.
- Contribution of sequences downstream of the TATA element to a protein-DNA complex containing the TATA-binding protein.
- A novel role for Cdc5p in DNA replication.
