A protein kinase associated with paired helical filaments in Alzheimer disease.
AUTOR(ES)
Vincent, I J
RESUMO
We have identified a protein kinase in immunoaffinity-purified preparations of paired helical filaments from brain tissue of individuals with Alzheimer disease. The kinase phosphorylates the filament proteins in vitro in a manner independent of second messenger regulation or of modulation by heparin and polyamines. Physiological concentrations of hemin, an oxidized heme porphyrin, inhibit the kinase and abolish Alz-50 immunoreactivity of the proteins. Since paired helical filaments are composed of hyperphosphorylated proteins, association of a protein kinase with the filaments provides a mechanism for abnormal processing of the proteins in disease.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=48766Documentos Relacionados
- Microtubule-associated protein tau (tau) is a major antigenic component of paired helical filaments in Alzheimer disease.
- Identification and localization of a tau peptide to paired helical filaments of Alzheimer disease.
- Paired helical filaments from Alzheimer disease patients contain cytoskeletal components.
- Straight and paired helical filaments in Alzheimer disease have a common structural unit.
- A nucleated assembly mechanism of Alzheimer paired helical filaments
