A tandem repeat gene in a picornavirus.

AUTOR(ES)

Forss, S

RESUMO

Three closely related genes for the small genome-linked protein (VPg) of picornaviruses have been identified by sequence analysis as a tandem repeat in the genome of Foot and Mouth Disease Virus (FMDV), strain O1K. This unusual structure was also found in the genome of strain C1O, belonging to a different FMDV serotype. Predicted biochemical properties of the three VPg gene products are in excellent agreement with the data from protein analysis of a heterogeneous VPg population from a third FMDV serotype, strain A10 (1). Taken together, these data indicate that the VPgs from all three genes function equally well in vivo. This is the first report of a tandem repeat gene in a viral genome.

Documentos Relacionados

• Temperature-sensitive RNA polymerase mutants of a picornavirus.
• Tandem repeat distribution of gene transcripts in three plant families
• Cloning and characterization of a core histone gene tandem repeat in Urechis caupo.
• Two human repetitive DNA elements: a new interspersed repeat found in the factor IX gene, and a satellite 11 tandem repeat sequence.
• New tandem repeat region in the non-transcribed spacer of human ribosomal RNA gene.