A viral gene that activates lytic cycle expression of Kaposi’s sarcoma-associated herpesvirus
AUTOR(ES)
Sun, Ren
FONTE
The National Academy of Sciences
RESUMO
Herpesviruses exist in two states, latency and a lytic productive cycle. Here we identify an immediate-early gene encoded by Kaposi’s sarcoma-associated herpesvirus (KSHV)/human herpesvirus eight (HHV8) that activates lytic cycle gene expression from the latent viral genome. The gene is a homologue of Rta, a transcriptional activator encoded by Epstein–Barr virus (EBV). KSHV/Rta activated KSHV early lytic genes, including virus-encoded interleukin 6 and polyadenylated nuclear RNA, and a late gene, small viral capsid antigen. In cells dually infected with Epstein–Barr virus and KSHV, each Rta activated only autologous lytic cycle genes. Expression of viral cytokines under control of the KSHV/Rta gene is likely to contribute to the pathogenesis of KSHV-associated diseases.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=27987Documentos Relacionados
- Kinetics of Kaposi’s Sarcoma-Associated Herpesvirus Gene Expression
- Kaposi’s Sarcoma-Associated Herpesvirus Viral Interferon Regulatory Factor
- Kaposi's Sarcoma-Associated Herpesvirus Latent and Lytic Gene Expression as Revealed by DNA Arrays
- Kaposi's sarcoma-associated herpesvirus infection and Kaposi's sarcoma in Brazil
- Virion Proteins of Kaposi's Sarcoma-Associated Herpesvirus
