Absorption and Excretion of Diquat and Paraquat in Rats

AUTOR(ES)

Daniel, J. W.

RESUMO

The fate of 14C-labelled diquat and paraquat after oral and subcutaneous administration of single doses has been studied in the rat. By both routes of administration the radioactivity usually appears in the excreta within two days. In a few cases a small amount is excreted in the urine on the third day or in faeces on the fourth day. After an oral dose of paraquat no radioactivity could be detected in bile, and with diquat less than 5% of the dose appeared in bile within 24 hours. Both diquat and paraquat are poorly absorbed from the gut, and after subcutaneous administration little or none appears in faeces.

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