Acquired chemotactic inhibitors during infection with guinea pig cytomegalovirus.
AUTOR(ES)
Tannous, R
RESUMO
Factors involved in neutrophil and monocyte migrations were serially studied in strain 2 guinea pigs undergoing initial cytomegalovirus infection and sham-inoculated controls. All studies remained unchanged in uninfected animals. Monocyte migrations and neutrophil spontaneous migration remained unchanged in infected animals. However, transient abnormalities occurred early in infection, comprising a decrease in neutrophil-directed migration towards C5-derived chemotactic fractions (C5-fr) and a decrease in the chemotactic activity of zymosan-activated plasma. Consequently, the presence of neutrophil- and chemotaxin-directed inhibitors in plasma was investigated. Normal neutrophils, C5-fr, Escherichia coli-derived bacterial factor, and the synthetic peptide F-met-leu-phe were first incubated with control or infected plasmas and then assayed for directed migration and lysosomal enzyme release. Results indicated the de novo appearance of both neutrophil- and chemotaxin-directed inhibitory activities in plasma during early infection. The neutrophil-directed inhibition was heat stable (56 degrees C for 120 min) and nonspecific (responses to all chemotaxins were inhibited). The chemotaxin-directed inhibition was heat stable and C5-fr specific. The cytomegalovirus-induced inhibitors may be important in the enhanced susceptibility to concurrent opportunistic infections.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=264747Documentos Relacionados
- Nonproductive Infection of Guinea Pig Cells with Human Cytomegalovirus
- Susceptibility of fetal guinea pig brain cell cultures to replicating guinea pig cytomegalovirus infection is increased with increasing fetal age: infection of astrocytes.
- Efficacy of S26308 against guinea pig cytomegalovirus infection.
- Susceptibility of lymphoblastoid cells to infection with human cytomegalovirus.
- Effect of 2'-nor-cyclic GMP against guinea pig cytomegalovirus infection.