Activation of human monocyte cell line U937 via cell surface calreticulin

AUTOR(ES)

Cho, Jang-Hyun

FONTE

Cell Stress Society International

RESUMO

U937 cells were found to be activated by an antibacterial peptide, KLKLLLLLKLK-NH2 (L5), to generate superoxide anion (O2−)-like peripheral neutrophils. However, the state of cell surface calreticulin, a possible receptor for L5, was suggested to differ between neutrophils and U937 cells. Unlike the former, the latter ones were activated by anti-C-domain peptide antibody of calreticulin even in the absence of L5 and generated O2− in a GTP-binding protein (G-protein)-dependent manner.

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