Activation of the 2′-N-Acetyltransferase Gene [aac(2′)-Ia] in Providencia stuartii by an Interaction of AarP with the Promoter Region
AUTOR(ES)
Macinga, David R.
FONTE
American Society for Microbiology
RESUMO
The aac(2′)-Ia gene in Providencia stuartii encodes a 2′-N-acetyltransferase capable of acetylating both peptidoglycan and certain aminoglycoside antibiotics. Regulation of the aac(2′)-Ia gene is influenced in a positive manner by the product of the aarP gene, which encodes a small transcriptional activator of the AraC (XylS) family. In this study, we demonstrate the sequence requirements at the aac(2′)-Ia promoter for AarP binding and activation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=89362Documentos Relacionados
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