Activities of two new antiviral agents against guinea pig lymphotropic herpesvirus infection in vitro.
AUTOR(ES)
Hu, J M
RESUMO
Two new antiviral agents, compound 164, also known as 2'-nor-cGMP (9-[(2-hydroxy-1,3,2-dioxaphosphorinan-5-yl)oxymethyl]-guani ne P-oxide), and compound 102 [4-amino-5-bromo-7-(2-hydroxyethoxymethyl)-pyrrolo(2,3-d)pyrimidine], together with acyclovir for comparison, were evaluated for activities against the guinea pig lymphotropic herpesvirus infection in vitro by plaque reduction and virus yield reduction assays in guinea pig embryo cells. The two new compounds were demonstrated to be more potent against guinea pig lymphotropic herpesvirus infections than acyclovir. Compound 164 was the most potent of the three; drug concentrations required to reduce the number of plaques by 50% were 2, 35.5, and 144.5 microM for compounds 164, 102, and acyclovir, respectively. The two new compounds were cytostatic but not cytotoxic to guinea pig embryo cells in cultures. Attempts were made to investigate the inhibition of viral replication by these compounds, and the influence of test conditions on antiviral evaluations is discussed.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=172709Documentos Relacionados
- Activities of Two New Antiviral Agents against Guinea Pig Lymphotropic Herpesvirus Infection In Vitro
- In vitro activities of nucleoside analog antiviral agents against salmonellae.
- Antiviral activities of guanosine analogs in guinea pig embryonic fibroblasts.
- In vitro activities in new oxazolidinone antimicrobial agents against enterococci.
- Guinea pig transfer factor-like activity detected in vitro.
