Activity and mode of action of acridine compounds against Leishmania donovani.
AUTOR(ES)
Mesa-Valle, C M
RESUMO
In the present work, we have assayed both the in vitro and in vivo action of two acridine compounds against Leishmania donovani. As part of this effort, we have studied the possible action mechanism of these compounds at the ultrastructural and biochemical levels and in relation to the synthesis of macromolecules. The two acridinones inhibit the in vitro growth of the promastigote forms of L. donovani at the highest concentration assayed (100 micrograms/ml). The in vivo results indicate that both compounds reduce the number of amastigotes per gram of spleen, and decrease parasitism, by more than 40%. With respect to the action mechanism, both compounds inhibit the incorporation of [3H]thymidine, inducing alterations at the ultrastructural level in the DNA and mitochondria. Alterations are also caused in the enzymes of the Krebs cycle.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=163180Documentos Relacionados
- Genetic analysis of nucleoside transport in Leishmania donovani.
- Antileishmanial activity of licochalcone A in mice infected with Leishmania major and in hamsters infected with Leishmania donovani.
- Stage-specific variations in lectin binding to Leishmania donovani.
- Purification and characterization of an 80-kilodalton membrane protein from Leishmania donovani.
- Susceptibilities of macrophage populations to infection in vitro by Leishmania donovani.