Activity of and Resistance to Moxifloxacin in Staphylococcus aureus

AUTOR(ES)

Ince, Dilek

FONTE

American Society for Microbiology

RESUMO

Moxifloxacin has enhanced potency against Staphylococcus aureus, lower propensity to select for resistant mutants, and higher bactericidal activity against highly resistant strains than ciprofloxacin. Despite similar activity against purified S. aureus topoisomerase IV and DNA gyrase, it selects for topoisomerase IV mutants, making topoisomerase IV the preferred target in vivo.

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