Activity of Colicin E3-Treated Ribosomes in Initiation and in Chain Elongation
AUTOR(ES)
Tai, Phang-Cheng
RESUMO
Colicin E3 (called E3 here) is shown to act on polysomal ribosomes as well as on free ribosomes. This treatment severely inhibits subsequent chain elongation, both on preformed polysomes completing their nascent chains and on ribosomes translating poly(U). Elevated Mg++ concentration relieves this inhibition. However, elevated Mg++ concentration does not relieve the inhibition of ribosomes initiating on natural messenger; hence damage by E3 appears to have an additional, specific effect on some stage in initiation.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=388153Documentos Relacionados
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