Activity of purine analogs against Leishmania donovani in vivo.
AUTOR(ES)
Berman, J D
RESUMO
The dose of orally administered 9-deazainosine calculated to suppress 50% of Leishmania donovani amastigotes in hamster livers was 19 mg/kg (body weight) per day; 96 to 99% of Leishmania organisms were eliminated from the liver and spleen of squirrel monkeys by 50 mg/kg per day. Because these activities were greater than that of the experimental clinical agent allopurinol and comparable to that of the classical agent parenteral pentavalent antimony, 9-deazainosine should be considered for clinical development for visceral leishmaniasis.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=174664Documentos Relacionados
- Activity of purine analogs against Leishmania tropica within human macrophages in vitro.
- Activity and mode of action of acridine compounds against Leishmania donovani.
- Stage-Specific Activity of Pentavalent Antimony against Leishmania donovani Axenic Amastigotes
- In Vivo Activities of Farnesyl Pyrophosphate Synthase Inhibitors against Leishmania donovani and Toxoplasma gondii
- Activity of a Heat-Induced Reformulation of Amphotericin B Deoxycholate (Fungizone) against Leishmania donovani