Activity of trovafloxacin in combination with other drugs for treatment of acute murine toxoplasmosis.
AUTOR(ES)
Khan, A A
RESUMO
Current therapy for toxoplasmosis with a synergistic combination of pyrimethamine plus sulfadiazine or pyrimethamine plus clindamycin is not always efficacious and is frequently discontinued due to intolerable toxic effects in immunocompromised individuals, particularly those with AIDS. Trovafloxacin, a new fluoroquinolone with potent activity against Toxoplasma gondii, was examined for potential synergistic activity when combined with other drugs used for treatment of human toxoplasmosis. Combinations of trovafloxacin with clarithromycin, pyrimethamine, or sulfadiazine demonstrated significantly enhanced activities compared to those observed with each drug alone. Our results suggest that combinations of trovafloxacin and other anti-toxoplasma drugs should be further explored for treatment of toxoplasmosis in humans.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=163821Documentos Relacionados
- Activity of clarithromycin alone or in combination with other drugs for treatment of murine toxoplasmosis.
- Treatment with interleukin 12 in combination with atovaquone or clindamycin significantly increases survival of mice with acute toxoplasmosis.
- Interleukin-12 enhances murine survival against acute toxoplasmosis.
- Synergistic activity of azithromycin and gamma interferon in murine toxoplasmosis.
- Synergistic activity of azithromycin and pyrimethamine or sulfadiazine in acute experimental toxoplasmosis.