Acute effects of continuous positive airway pressure on mucociliary clearance of healthy subjects: the impact of humidification and air leak / Efeitos agudos da pressão positiva contínua de vias aéreas (CPAP) e impacto da umidificação e vazamento aéreo sobre o transporte mucociliar e inflamação nasal de indivíduos sadios

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

Continuous positive airway pressure (CPAP) is the treatment of choice for patients with Obstructive Sleep Apnea but yet nasal symptoms are often reported. Air leaks and changes of the respiratory epithelium are important in the development of nasal symptoms and heated humidification is used to alleviate these symptoms. The aim of this study was to investigate the acute effects of CPAP and the impact of heated humidification and air leak on the nasal mucociliary clearance and nasal inflammation of healthy volunteers. To this end we evaluated nasal mucociliary clearance in vivo (through the Saccharin Test), in vitro nasal mucus transportability (through the Frog Palate Model), nasal lavage and respiratory symptoms (through a Visual Analogue Scale) of sixteen healthy volunteers before and after acute CPAP application under different conditions: CPAP with and without heated humidification and with and without air leak. In vivo nasal mucociliary clearance increased significantly after all CPAP interventions. There was no significant difference in mucus transportability, total or differential inflammatory cell count from the nasal lavage after any CPAP intervention. There was a significant increase in the subjective perception of the respiratory symptoms studied after the use of CPAP without humidification and with air leak. We conclude that the acute use of CPAP independently of humidification or air leak significantly increases in vivo nasal mucociliary clearance, doesnt change mucus transportability and total or differential cell count. However, the use o CPAP without humidification and with air leak significantly increased nasal and throat dryness, coryza and nasal obstruction subjective perception.

ASSUNTO(S)

sacarina/ uso diagnóstico respiratory signs and symptoms nasal lavage fluid pressão positiva contínua nas vias aérea líquido da lavagem nasal. continuous positive airway pressure mucociliary clearance saccharin/ diagnostic use depuração mucociliar sinais e sintomas respiratórios

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