Addition of Caspofungin to Fluconazole Does Not Improve Outcome in Murine Candidiasis

AUTOR(ES)

Graybill, John R.

FONTE

American Society for Microbiology

RESUMO

Caspofungin is a potent antifungal inhibiting glucan synthesis in Candida species. However, caspofungin is not 100% curative in candidiasis. Therefore, we evaluated combinations of fluconazole with caspofungin for murine candidemia. We could not show any benefit of combined therapy over individual antifungal drugs.

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