Afut1, a retrotransposon-like element from Aspergillus fumigatus.
AUTOR(ES)
Neuveglise, C
RESUMO
A repeated DNA sequence used for epidemiological studies of the human opportunistic pathogen Aspergillus fumigatus has been characterized. It is a retroelement of 6914 bp in length, bounded by long terminal repeats of 282 bp, with sequence and features characteristic of retroviruses and retrotransposons. A 5 bp duplication site was found at its borders. This element, designated Afut1, encodes amino acid sequences homologous to the reverse transcriptase, RNase H and endonuclease encoded by the pol genes of retroelements. Comparison of the peptidic sequences with other putative polypeptides of fungal LTR retrotransposons showed that Afut1 is a member of the gypsy group. This is the first report of a transposable element in A.fumigatus. Afut1 is a defective element: the putative coding domains contain multiple stop codons due exclusively to transitions from C:G to T:A.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=145799Documentos Relacionados
- A temperature-regulated, retrotransposon-like element from Candida albicans.
- Tca1, the Retrotransposon-Like Element of Candida albicans, Is a Degenerate and Inactive Element
- A novel family of retrotransposon-like elements in Xenopus laevis with a transcript inducible by two growth factors.
- Retrotransposon-like nature of Tp1 elements: implications for the organisation of highly repetitive, hypermethylated DNA in the genome of Physarum polycephalum.
- Itraconazole resistance in Aspergillus fumigatus.