Aggregation of recombinant human interferon alpha 2b in solution: Technical note

AUTOR(ES)

Ruiz, Llamil

FONTE

Springer-Verlag

RESUMO

Sodium phosphate buffer increased the aggregation of rhIFN-α2b in the range of 1.55 to 1.8103 day−1, as determined by SDS/PAGE under reduced and nonreduced conditions. In contrast, sodium citrate buffer decreased the aggregation rate of this cytokine, as compared with those samples in sodium phosphate buffer. Results from sodium citrate-phosphate buffer were very similar to those obtained with sodium citrate solutions.

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