Aggressive behavior induces release of nerve growth factor from mouse salivary gland into the bloodstream.

AUTOR(ES)

Aloe, L

RESUMO

Intraspecific fighting induced by 6-8 weeks of social isolation results in massive release of nerve growth factor (NGF) into the bloodstream of adult male mice. The amount of circulating NGF is highly correlated with the number of fighting episodes. Biological, radioimmunological, immunohistochemical, and ultrastructural studies show that NGF is discharged from the salivary gland into the blood within minutes after fighting and reaches the highest level 3-4 hr later. Adrenergic innervation of the salivary gland or adrenalectomy does not abolish the NGF release. Corticotropic hormones do not induce NGF increase in the blood. Daily administrations of highly purified NGF (3 micrograms per g of body weight) result in a considerable increase in the volume of adrenal glands. These findings are unequivocable evidence for a physiological role of the mouse salivary glands as a major source of blood NGF.

Documentos Relacionados

• Nerve Growth Factor from Mouse Submaxillary Gland: Amino Acid Sequence
• PURIFICATION OF A NERVE-GROWTH PROMOTING PROTEIN FROM THE MOUSE SALIVARY GLAND AND ITS NEURO-CYTOTOXIC ANTISERUM*
• Subunit structure of a high-molecular-weight form of the nerve growth factor from mouse submaxillary gland.
• Nerve growth factor in mouse serum and saliva: role of the submandibular gland.
• Nerve growth factor in mouse serum and saliva: Role of the submadibular gland