Agonist-specific coupling of a cloned Drosophila octopamine/tyramine receptor to multiple second messenger systems.

AUTOR(ES)

Robb, S

RESUMO

A cloned seven transmembrane-spanning Drosophila octopamine/tyramine receptor, permanently expressed in a Chinese hamster ovary cell line, both inhibits adenylate cyclase activity and leads to the elevation of intracellular Ca2+ levels by separate G-protein-coupled pathways. Agonists of this receptor (octopamine and tyramine), differing by only a single hydroxyl group in their side chain, may be capable of differentially coupling it to different second messenger systems. Thus, a single receptor may have a different pharmacological profile depending on which second messenger system is used to assay its efficacy.

Documentos Relacionados

• Agonist-specific conformational changes in the yeast alpha-factor pheromone receptor.
• Structural determinants of agonist-specific kinetics at the ionotropic glutamate receptor 2
• Cloned human neuropeptide Y receptor couples to two different second messenger systems.
• Role for G protein-coupled receptor kinase in agonist-specific regulation of μ-opioid receptor responsiveness
• Separate agonist-specific oscillatory mechanisms in cultured human sweat duct cells.