Aldose Reductase-Deficient Mice Develop Nephrogenic Diabetes Insipidus
AUTOR(ES)
Ho, Horace T. B.
FONTE
American Society for Microbiology
RESUMO
Aldose reductase (ALR2) is thought to be involved in the pathogenesis of various diseases associated with diabetes mellitus, such as cataract, retinopathy, neuropathy, and nephropathy. However, its physiological functions are not well understood. We developed mice deficient in this enzyme and found that they had no apparent developmental or reproductive abnormality except that they drank and urinated significantly more than their wild-type littermates. These ALR2-deficient mice exhibited a partially defective urine-concentrating ability, having a phenotype resembling that of nephrogenic diabetes insipidus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=86061Documentos Relacionados
- Isolation of Dihydrofolate Reductase-Deficient Mutant of Escherichia coli
- Nitrate Utilization by Nitrate Reductase-deficient Barley Mutants 1
- Nitrate Reductase mRNA Regulation in Nicotiana plumbaginifolia Nitrate Reductase-Deficient Mutants.
- Isolation of a dihydrofolate reductase-deficient mutant of Escherichia coli.
- Nitrogen fixation in nitrate reductase-deficient mutants of cultured rhizobia.
