Allogeneic H-2 antigen expression is insufficient for tumor rejection.

AUTOR(ES)

Cole, G A

RESUMO

Murine A strain (KkDdLd) sarcoma I (SaI) tumor cells have been transfected with a cloned H-2Kb gene. The resulting clones (SKB clones) stably express high levels of a molecule that is serologically and biochemically indistinguishable from the H-2Kb antigen. SKB clones are not susceptible to cytotoxic T lymphocyte-mediated lysis by H-2Kb-specific bulk, cloned, or H-2Kb-restricted lymphocytic choriomeningitis virus-specific effectors. Survival times of A/J and B10.A mice challenged i.p. with the H-2Kb-expressing transfectants and the parental SaI cells are similar, suggesting that the presence of an allogeneic major histocompatibility complex class I antigen on the surface of this tumor line is insufficient for tumor rejection.

Documentos Relacionados

• Identification of a human melanoma antigen recognized by tumor-infiltrating lymphocytes associated with in vivo tumor rejection.
• H-2 antigen expression on teratocarcinoma cells passaged in genetically resistant mice is regulated by lymphoid cells
• H-2 restriction: Independent recognition of H-2 and foreign antigen by a single receptor
• Endogenous retroviruses lead to the expression of a histocompatibility antigen detectable by skin graft rejection.
• Tolerance of thymic cytotoxic T lymphocytes to allogeneic H-2 determinants encountered prethymically: evidence for expression of anti-H-2 receptors prior to entry into the thymus.