Alphavirus Replicase Protein NSP1 Induces Filopodia and Rearrangement of Actin Filaments

AUTOR(ES)

Laakkonen, Pirjo

FONTE

American Society for Microbiology

RESUMO

Expression of the NSP1 protein of Semliki Forest virus and Sindbis virus in cultured cells induced filopodia-like extensions containing NSP1 but not F actin. The actin stress fibers disappeared, whereas vimentin, keratin, and tubulin networks remained intact. The effects of NSP1 were dependent on its palmitoylation but not on its enzymatic activities and were also observed in virus-infected cells.

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