Amino Acid Sequence of the Light Chain from a Mouse Myeloma Protein with Anti-Hapten Activity: Evidence for a Third Type of Light Chain
AUTOR(ES)
Schulenburg, Elizabeth P.
RESUMO
A tentative amino acid sequence has been determined for the light chain of a mouse A-myeloma (MOPC-315) protein with anti-2,4-dinitrophenyl activity. An unusual amino acid sequence in the carboxyl-terminal 104 residues suggests that the chain represents a new class of immunoglobulin light chain. The “variable” segment of this chain (amino-terminal 110 residues) differs at only eight positions from the corresponding segment of the lambda chain of a mouse M-myeloma (MOPC-104) protein with anti-dextran activity.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=389486Documentos Relacionados
- Amino-Acid Sequence of the Variable Region of the Heavy (Alpha) Chain of a Mouse Myeloma Protein with Anti-Hapten Activity
- Antibody engineering for the analysis of affinity maturation of an anti-hapten response.
- Dissociation of the anti-hapten and anti-carrier responses of mice injected with dinitrophenylated lipopolysaccharide.
- Corrigendum: Antibody engineering for the analysis of affinity maturation of an anti-hapten response
- Stimulation and inhibition of anti-hapten responses in guinea pigs immunized with hybrid liposomes.