An electrophysiological study of excitatory neuromuscular transmission in the guinea-pig main pulmonary artery.
AUTOR(ES)
Suzuki, H
RESUMO
Electrical responses of single smooth muscle cells to perivascular nerve stimulation were recorded in the guinea-pig main pulmonary artery with a micro-electrode, to investigate neuromuscular transmission mechanisms. Perivascular nerve stimulation produced excitatory junction potentials in the smooth muscle cells of the main pulmonary artery. When stimulation was repetitive and of high frequency, a spike was seen in the early part of these potentials. Phentolamine, prazosin, phenoxybenzamine, guanethidine or tetrodotoxin all suppressed first the spike and then the junction potential. Exogenously applied noradrenaline also produced depolarization, and in high concentrations above 10(-6) M, spikes. Phentolamine again suppressed the spikes and then the depolarization. The results suggest that endogenous and exogenous noradrenaline act on the same type of receptor in this artery.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=1198954Documentos Relacionados
- Modulation of noradrenergic transmission in the guinea-pig mesenteric artery: an electrophysiological study.
- Neuromuscular transmission and smooth muscle membrane properties in the guinea-pig ear artery
- Electrophysiology of neuromuscular transmission in guinea-pig mesenteric veins.
- Modulation of neuromuscular transmission by endogenous and exogenous prostaglandins in the guinea-pig mesenteric artery
- Electrophysiological properties of guinea-pig thalamic neurones: an in vitro study.
