An embryonic DNA-binding protein specific for the promoter of the retrovirus long terminal repeat.
AUTOR(ES)
Flamant, F
RESUMO
Retrovirus expression is restricted in embryonal carcinoma (EC) cells but not in many differentiated cell lines. We used a very sensitive gel retardation assay to detect sequence-specific DNA-binding proteins in crude nuclear extracts obtained from EC and differentiated cells. Four binding sites were mapped in the noncoding sequences of the amphotropic murine leukemia virus. Strong binding to the CCAAT consensus sequence located in the promoter was specifically observed with EC nuclear extract. The binding protein is called EPBF (embryonal promoter-binding factor), and it is a candidate for the repressor of retrovirus transcription.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=368007Documentos Relacionados
- An embryonic DNA-binding protein specific for a region of the human IFN beta 1 promoter.
- A cyclic AMP-responsive DNA-binding protein (CREB2) is a cellular transactivator of the bovine leukemia virus long terminal repeat.
- Avian Retrovirus pp32 DNA-Binding Protein I. Recognition of Specific Sequences on Retrovirus DNA Terminal Repeats
- DNA-binding proteins that interact with the long terminal repeat of radiation leukemia virus.
- Multiple protein-binding sites in an intracisternal A particle long terminal repeat.
