An erythroid specific enhancer upstream to the gene encoding the cell-type specific transcription factor GATA-1.
AUTOR(ES)
Nicolis, S
RESUMO
The transcription factor GATA-1 is expressed in a subset of hemopoietic cells, where it mediates the cell-type specific expression of several genes. We have cloned the mouse and human GATA-1 genes. A region upstream to the first exon, and highly conserved between mouse and man, acts as an erythroid specific enhancer in transient assays, if linked to the GATA-1 or to the SV40 promoter. The activity of the enhancer is almost completely dependent on the integrity of a dimeric GATA-1 binding site.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=328889Documentos Relacionados
- Structure and promoter activity of the gene for the erythroid transcription factor GATA-1.
- Estrogen-induced apoptosis by inhibition of the erythroid transcription factor GATA-1.
- The HLA-DQ beta gene upstream region contains an immunoglobulin-like octamer motif that binds cell-type specific nuclear factors.
- urbs1, a gene regulating siderophore biosynthesis in Ustilago maydis, encodes a protein similar to the erythroid transcription factor GATA-1.
- Cell-type specific adhesive interactions of skeletal myoblasts with thrombospondin-1.