Análise morfológica renal de ratas prenhes submetidas ao estresse / Renal morphological analysis of pregnant rats submitted to stress

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

This study evaluated the kidneys from pregnant and non-pregnant Wistar rats exposed to chronic stress and its respective control groups. The chronic stress consisted of noise exposure (30 minutes of 100-dB each two hours interval) and super-population between the 7th and 14th day and the acute stress of thirty minutes immobilization in the 18th of pregnancy two days before the end of the experiment. All the rats were killed in the 20th day of protocol. The kidneys were studied and also the weight of the rats in the 1st, 7th, 14th and 20th day, the caudal artery blood pressure in the 5th and 18th day, and the fetus and placentas weight. There were not seen any alteration using light microscopy in the kidney of rats submitted to stress; although it was observed a significant increase in systolic (154.4 ± 14.2 mmHg) and diastolic (89.0 ± 8.7 mmHg) caudal blood pressure in the 18th day in the pregnant stress group (p <0.05) in relation to the control group (129.1 ± 13.1 mmHg and 79.9 ± 18.1 mmHg, respectively) and a decrease in fetal (2.54 ± 0.32g) and placenta (0.53 ± 0.09g) weight in the 20th day in the pregnant stress group (p <0.001) in relation to the control group (2.95 ± 0.53g and 0.60 ± 0.08g, respectively). The analyzed model may be employed to evaluate the intrauterine growth restriction in rats, caused by chronic stress, probably induced by hypertension during the pregnancy

ASSUNTO(S)

kidney/anatomy &histology ratos estresse rats prenhez pregnancy stress immobilization imobilização rim/anatomia &histologia

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