Analysis of a complete homeobox gene repertoire: Implications for the evolution of diversity

AUTOR(ES)

Kappen, Claudia

FONTE

The National Academy of Sciences

RESUMO

The completion of sequencing projects for various organisms has already advanced our insight into the evolution of entire genomes and the role of gene duplications. One multigene family that has served as a paradigm for the study of gene duplications and molecular evolution is the family of homeodomain-encoding genes. I present here an analysis of the homeodomain repertoire of an entire genome, that of the nematode Caenorhabditis elegans, in relation to our current knowledge of these genes in plants, arthropods, and mammals. A methodological framework is developed that proposes approaches for the analysis of homeodomain repertoires and multigene families in general.

Documentos Relacionados

• Patterned acquisition of the antibody repertoire: diversity of the hemagglutinin-specific B-cell repertoire in neonatal BALB/c mice.
• Molecular cloning of the primary IgH repertoire: a quantitative analysis of VH gene usage in adult mice.
• A gene fusion at a homeobox locus: alterations in leaf shape and implications for morphological evolution.
• A gene cluster for secondary metabolism in oat: Implications for the evolution of metabolic diversity in plants
• Complete nucleotide sequence of a functional class I HLA gene, HLA-A3: implications for the evolution of HLA genes.