Analysis of the Events Leading to SV40-Induced Chromosome Replication and Mitosis in Primary Mouse Kidney Cell Cultures
AUTOR(ES)
May, Evelyne
RESUMO
Abortive infection with simian virus 40 in confluent, “contact-inhibited”, mouse kidney cell cultures was studied. The sequential events, in individual cells, are tentatively represented by the simplified scheme: (a) transcription of early virus-specific (messenger) RNA; (b) appearance of T-antigen; (c) [psychrosensitive event(s)]; (d) chromosome replication; (e) normal or abnormal mitosis. No evidence for the replication of viral progeny DNA was obtained. The sequence of the events (a)-(d) is analogous to that observed in contact-inhibited mouse kidney tissue culture cells during lytic infection with polyoma virus.
ACESSO AO ARTIGO
http://www.pubmedcentral.nih.gov/articlerender.fcgi?artid=389155Documentos Relacionados
- Antigenic Study of Unfertilized Mouse Eggs: Cross Reactivity with SV40-Induced Antigens*
- THE NATURE AND LOCALIZATION OF THE SV40-INDUCED COMPLEMENT-FIXING ANTIGEN*
- The mechanism of internuclear transmission of SV40-induced complement fixation antigen in heterokaryocytes.
- AN ANALYSIS OF SV40-INDUCED TRANSFORMATION OF HAMSTER KIDNEY TISSUE IN VITRO, II. STUDIES OF THREE CLONES DERIVED FROM A CONTINUOUS LINE OF TRANSFORMED CELLS
- Simian Virus 40 Deoxyribonucleic Acid Replication: I. Effect of Cycloheximide on the Replication of SV40 Deoxyribonucleic Acid in Monkey Kidney Cells and in Heterokaryons of SV40-transformed and Susceptible Cells